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KMID : 1134820140430081158
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Journal of the Korean Society of Food Science and Nutrition
2014 Volume.43 No. 8 p.1158 ~ p.1165
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Anti-inflammatory Effect of Ethanol Extract from Sargassum fulvellum on Lipopolysaccharide Induced Inflammatory Responses in RAW 264.7 Cells and Mice Ears
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Jeong Da-Hyun
Kim Koth-Bong-Woo-Ri
Kim Min-Ji
Kang Bo-Kyeong
Bark Si-Woo
Pak Won-Min
Kim Bo-Ram
Ahn Na-Kyung
Choi Yeon-Uk
Ahn Dong-Hyun
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Abstract
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This study investigated the anti-inflammatory effects of Sargassum fulvellum ethanol extract (SFEE) on the lipopolysaccharide (LPS)-induced inflammatory response. SFEE remarkably suppressed production of NO and pro-inflammatory cytokines (IL-6, TNF-α, and IL-1β) at 50 and 100 μg/mL. There were no cytotoxic effects on proliferation of macrophages treated with SFEE compared to the control. SFEE reduced expression of iNOS and COX-2 proteins in a dose-dependent manner. The formation of edema in mouse ears was reduced at the highest dose tested compared to the control. Moreover, in the acute toxicity test, no mortality occurred in mice administered 5,000 mg/kg body weight of SFEE over the 2-week observation period. These results suggest that SFEE may have significant effects on inflammatory factors and be a potential anti-inflammatory therapeutic material.
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KEYWORD
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anti-inflammatory effect, NF-κB, pro-inflammatory cytokines, Sargassum fulvellum
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